Ovarian Biomarkers in Infertility

The female infertility is a complex phenomenon that at least in part resides in the manifestation, possible perturbations and interplay of innate and adaptive immunity, with the participation of apoptotic and reactive oxygen species pathways, and some paracrine factors as causative and implementing factors in this process. The spread of the assisted reproduction technologies provided an unseen before opportunity to the intimacy of the ovarian follicle – the oocyte cellular surroundings and the oocyte itself, enabling research and medical community to boost the pursuit of new ovarian function biomarkers in the context of gamete fertilization and embryo development competence. The notion of infertility markers would be presented in a comprehensive viewpoint based on the importance of the folliculogenesis, oocyte-cumulus-granulosa cells interactions and oocyte genesis. This approach is aimed on the provision of non-invasive means for oocyte and embryo competence evaluation and improved reproductive medicine outcome.